Mitochondrial Dynamics in Diabetic Cardiomyopathy

Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations.

Diabetic cardiomyopathy is the leading cause of heart failure among diabetic patients, and mitochondrial dysfunction has been implicated as an underlying cause in the pathogenesis. Cardiac mitochondria consist of two spatially, functionally, and morphologically distinct subpopulations, termed subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM). SSM are situated beneath the p...

Proxisome prolifrator-activated receptors alpha and delta in diabetic cardiomyopathy

Peraxisome prolifrator-activated receptors (PPARs) are a group of nuclear receptors comprising three isoforms termed alpha, beta/delta and gamma. PPARs can modulate metabolic processes especially fatty acid (FA) metabolisms via exerting transcriptional control on activating genes involved in fuel utilization. Thus, they can exert positive role in controlling chronic diseases such as diabetes. A...

Effect of 6 weeks of resistance exercise preconditioning on mitochondrial dynamics in cardiac tissue of diabetic rats

Background and Objectives: Diabetic cardiomyopathy refers to changes in the heart as a result of altered glucose homeostasis, leading to ventricular dysfunction, and it is associated with the mitochondrial abnormality. Since physical exercise has been known as cardioprotective, the aim of the present study was to investigate the effect of 6 weeks of resistance exercise preconditioning on mitoch...

Diabetic cardiomyopathy

Diabetic cardiomyopathy.

I t has been over 30 years since Rubler et al. (1) described four diabetic patients with congestive heart failure (CHF), normal coronary arteries, and no other etiologies for CHF and proposed that it was due to diabetic cardiomyopathy. Eight years ago, I reviewed the evidence for diabetic cardiomyopathy as a unique entity unassociated with coronary artery disease and concluded that diabetic car...